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Transgenerational epigenetic inheritance Wikipedia ~ Transgenerational epigenetic inheritance is the transmission of epigenetic markers from one organism to the next that affects the traits of offspring without alteration of the primary structure of DNA —in other words epigenetically The less precise term epigenetic inheritance may cover both cell–cell and organism–organism information transfer Although these two levels of epigenetic inheritance are equivalent in unicellular organisms they may have distinct mechanisms and

Transgenerational Epigenetics ScienceDirect ~ Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations Recent research points to the existence of biological phenomena that are controlled not through gene mutations but rather through reversible and heritable epigenetic processes

Transgenerational Epigenetics 1st Edition ~ Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations Recent research points to the existence of biological phenomena that are controlled not through gene mutations but rather through reversible and heritable epigenetic processes

3 Examples of Transgenerational Epigenetic Inheritance ~ It is probably unlikely that transgenerational epigenetic inheritance is a widespread phenomenon Certainly epigenetics plays a major role in differentiating cell types within a given organism and “adapting” these tissues to environmental exposure Further there is significant evidence that these changes can occur in the gametes

A critical view on transgenerational epigenetic ~ Roadmap to proving transgenerational epigenetic inheritance 1 Rule out genetic ecological and cultural inheritance 2 Identify the responsible epigenetic factor in the germ cells 3 Demonstrate that the epigenetic factor in the germ cells is responsible

Transgenerational Epigenetic Inheritance myths and mechanisms ~ As with classical DNA sequence mutations most epigenetic “mutations” epialleles are either neutral or deleterious frequently involving the unleashing of transposable elements and other genomic parasites But transgenerational epigenetic inheritance has also the potential to be adaptive and in some cases

Intergenerational and transgenerational epigenetic ~ Animals transmit not only DNA but also other molecules such as RNA proteins and metabolites to their progeny via gametes It is currently unclear to what extent these molecules convey information between generations and whether this information changes according to their physiological state and environment

Transgenerational epigenetic inheritance More questions ~ The best evidence for transgenerational epigenetic inheritance in the mouse comes from the study of epialleles such as agouti viable yellow and axin fused in which DNA methylation levels of intracisternal A particle IAP retrotransposons control the expression of the neighboring gene